Author(s) Donald K. Blumenthal, PhD, and Derek Cowan

Pathology Video URL

Antiplatelet Drugs: This animation illustrates the various mechanisms by which antiplatelet drugs act to prevent normal and pathological thromboses.

From: Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e

_{CHAPTER EXCERPT}

Commonly confused conditions and entities relating to liver, biliary and pancreatic pathology

_{Liver, biliary system and pancreas›Pancreas›Diseases of the pancreas›Cystic lesions}

_{Unlabelled tableCommonly confusedDistinction and explanationCholestasis and jaundiceCholestasis is retention of bile in the liver, where histologically it is seen in liver cells and in the canaliculi between them. This can be due to disease of liv...}

_{Underwood's Pathology.}

_{CHAPTER EXCERPT}

Microscopic Pathology

_{Tumors of the Female Genital Tract›…›Sex Cord–Stromal Tumors›Thecoma}

_{The tumor is composed of fascicles or sheets of plump, spindled, or ovoid stromal cells that resemble the cells of the theca interna ( Fig. 13A.51). 236 The neoplastic cells have pale round or fusiform nuclei with fine, dispersed chromatin. The nu...}

_{Diagnostic Histopathology of Tumors.}

_{Fletcher, Christopher D.M., MD, FRCPath.. Published January 1, 2021. © 2021.}

_{See more results from this chapter}

Video

 

Supplemental Video S9 - Immunolabeling of Cleared Human Pancreata Provides Insights into Three-Dimensional Pancreatic Anatomy and Pathology

Three-dimensional imaging of human pancreatic ductal adenocarcinoma and its relationship to blood vessels. A section of grossly identified human pancreatic ductal adenocarcinoma was immunolabeled with antibodies for cytokeratin 19 (CK19) and clear...

Noë, Michaël; Rezaee, Neda; Asrani, Kaushal; Skaro, Michael; Groot, Vincent P.; Wu, Pei-Hsun; Olson, Matthew T.; Hong, Seung-Mo; Kim, Sung Joo; Weiss, Matthew J.; Wolfgang, Christopher L.; Makary, Martin A.; He, Jin; Cameron, John L.; Wirtz, Denis; Roberts, Nicholas J.; Offerhaus, G. Johan A.; Brosens, Lodewijk A.A.; Wood, Laura D.; Hruban, Ralph H... Published July 1, 2018. Volume 188, Issue 7. Pages 1530-1535. © 2018.

Pathology and genetics of hereditary colorectal cancer 

Pathology.
Ma, Huiying; Brosens, Lodewijk A.A.; Offerhaus, G. Johan A.; Giardiello, Francis M.; de Leng, Wendy W.J.; Montgomery, Elizabeth A... Published January 1, 2018. Volume 50, Issue 1. Pages 49-59. © 2017.

Pathology and genetics of hereditary colorectal cancer 

Pathology of fore and midgut neuroendocrine tumours

Figure 2:The general mechanisms of NETs include alterations of the WNT pathways, MAPK pathways, chromatin organization and angiogenesis. These cellular processes have key regulators that include known genes related with inherited syndromes with these neopl... MORE

Diagnostic Histopathology.

Diaz-Cano, Salvador J... Published October 1, 2012. Volume 18, Issue 10. Pages 421-436. © 2012

Pathology, Molecular Biology, and Pathogenesis of Avian Influenza A (H5N1) Infection in Humans

Figure 1:Examples of results of in situ hybridization, IHC, and lectin staining in various organs of H5N1 autopsies. A: Lung tissue showing severe damage, hyaline membrane formation, edema, fibrin exudation, and cellular infiltration (H & E staining). B: D... MORE

American Journal of Pathology, The.

Korteweg, Christine, M.D.; Gu, Jiang, M.D., Ph.D... Published May 1, 2008. Volume 172, Issue 5. Pages 1155-1170. © 2008

 

Pathology and Pathogenesis of Severe Acute Respiratory Syndrome

Figure 1:Pathology in the lungs, brain, and spleen. A: Lung tissue of a SARS autopsy showing severe damage, hyaline membrane formation, edema, fibrin exudation, and some inflammatory cells (H & E staining). Sample from a 50-year-old male SARS patient who d... MORE

American Journal of Pathology, The.

Gu, Jiang; Korteweg, Christine.. Published April 1, 2007. Volume 170, Issue 4. Pages 1136-1147. © 2007.

Color Atlas of Hematology. Practical Microscopic and Clinical Diagnosis

Source: Theml H, Diem H, Haferlach T, ed. 2nd Edition. Thieme; 2004. doi:10.1055/b-005-148949

Color Atlas of Pathology: Pathologic Principles · Associated Diseases · Sequela

Source: Riede U, Werner M, ed. 1st Edition. Thieme; 2004. doi:10.1055/b-005-148921

Microbiology in Your Pocket. Quick Pathogen Review

Source: Harriott M, ed. 1st Edition. Thieme; 2017. doi:10.1055/b-005-148868

Differential Diagnosis in Neurology and Neurosurgery: A Clinician’s Pocket Guide

Source: Tsementzis S, ed. Differential Diagnosis in Neurology and Neurosurgery: A Clinician’s Pocket Guide. 2nd Edition. 2019.

Fig. 2.23 (a) Radiographic criteria for basilar impression. 1: McGregor’s line between hard palate (HP) and the lowest point of occiput. Basilar impression is present if the dens protrudes more than 5 mm above this line. 2: Chamberlain’s line between hard palate and opisthion. Positive diagnosis if dens protrudes more than 2.5 mm above line.

Thieme Test Prep for the USMLE®: Clinical Anatomy Q&A

Source: Riede U, Werner M. Color Atlas of Pathology. 1st Edition. Thieme; 2004.

Source: Hankin M, Morse D, Venuti J et al., ed. Thieme Test Prep for the USMLE®: Clinical Anatomy Q&A. 1st Edition. 2019

Differential Diagnosis in Neurology and Neurosurgery: A Clinician’s Pocket Guide.

Fig. 2.23 (a) Radiographic criteria for basilar impression. 1: McGregor’s line between hard palate (HP) and the lowest point of occiput. Basilar impression is present if the dens protrudes more than 5 mm above this line. 2: Chamberlain’s line between hard palate and opisthion. Positive diagnosis if dens protrudes more than 2.5 mm above line.

Source: Tsementzis S, ed. Differential Diagnosis in Neurology and Neurosurgery: A Clinician’s Pocket Guide. 2nd Edition. 2019.

Thieme Test Prep for the USMLE®: Clinical Anatomy Q&A

Source: Yablon C, Jacobson J. Rotator cuff and subacromial pathology. Semin Musculoskelet Radiol. 2015; 19(03): 231–242.

Source: Hankin M, Morse D, Venuti J et al., ed. Thieme Test Prep for the USMLE®: Clinical Anatomy Q&A. 1st Edition. 2019.

TEXTBOOKS

Applied Physical Pharmacy, 3e

W. Cary Mobley, Mansoor M. Amiji, Thomas J. Cook

TEXTBOOKS

Pharmacy Calculations: A Video Lecture Review

W. Cary Mobley, Ph.D., R.Ph.

•Chapter 2: Mathematical Fundamentals in Pharmacokinetics

•Chapter 3: Biostatistics

•Chapter 4: One-Compartment Open Model: Intravenous Bolus Administration

•Chapter 5: Multicompartment Models: Intravenous Bolus Administration

•Chapter 6: Intravenous Infusion

•Chapter 7: Drug Elimination, Clearance, and Renal Clearance

•Chapter 8: Pharmacokinetics of Oral Absorption

•Chapter 9: Multiple-Dosage Regimens

•Chapter 10: Nonlinear Pharmacokinetics

•Chapter 11: Physiologic Drug Distribution and Protein Binding

•Chapter 12: Drug Elimination and Hepatic Clearance

•Chapter 13: Pharmacogenetics and Drug Metabolism

•Chapter 14: Physiologic Factors Related to Drug Absorption

•Chapter 15: Biopharmaceutic Considerations in Drug Product Design and In Vitro Drug Product Performance

•Chapter 16: Drug Product Performance, In Vivo: Bioavailability and Bioequivalence

•Chapter 17: Biopharmaceutical Aspects of the Active Pharmaceutical Ingredient and Pharmaceutical Equivalence

•Chapter 18: Impact of Biopharmaceutics on Drug Product Quality and Clinical Efficacy

•Chapter 19: Modified-Release Drug Products and Drug Devices

•Chapter 20: Targeted Drug Delivery Systems and Biotechnological Products

•Chapter 21: Relationship Between Pharmacokinetics and Pharmacodynamics

•Chapter 22: Application of Pharmacokinetics to Clinical Situations

•Chapter 23: Application of Pharmaco­kinetics to Specific Populations: Geriatric, Obese, and Pediatric Patients

•Chapter 24: Dose Adjustment in Renal and Hepatic Disease

•Chapter 25: Empirical Models, Mechanistic Models, Statistical Moments, and Noncompartmental Analysis

•Appendix A: Applications of Software Packages in Pharmacokinetics

•Appendix B: Glossary

TEXTBOOKS

Pharmacy Calculations: A Video Lecture Review

W. Cary Mobley, Ph.D., R.Ph.

TEXTBOOKS

Pharmacy Management: Essentials for All Practice Settings, 5e

David P. Zgarrick, Shane P. Desselle, Leticia R. Moczygemba, Greg Alston

VIDEOS

Supplemental Video Chapter

Pharmacy Calculations: A Video Lecture Review

28 mins, 28 secs

View in context

VIDEOS

Supplemental Video Chapter

Pharmacy Calculations: A Video Lecture Review

21 mins, 30 secs

View in context

VIDEOS

Supplemental Video Chapter

Pharmacy Calculations: A Video Lecture Review

21 mins, 30 secs

View in context

VIDEOS

Supplemental Video Chapter

Pharmacy Calculations: A Video Lecture Review

11 mins, 48 secs

View in context

IMAGES

MERCHANDISING

in Pharmacy Management: Essentials for All Practice Settings, 4e

View in context

IMAGES

MERCHANDISING

in Pharmacy Management: Essentials for All Practice Settings, 5e

View in context

IMAGES

MERCHANDISING

in Pharmacy Management: Essentials for All Practice Settings, 5e

View in context

IMAGES

MERCHANDISING

in Pharmacy Management: Essentials for All Practice Settings, 5e

View in context

BOOK CHAPTER

CHAPTER 32: APPLICATIONS IN INDEPENDENT COMMUNITY PHARMACY

Book Title : Chapter 31: Opioid Analgesics & Antagonists

BOOK CHAPTER

Chapter 62: Cardioactive Steroids >  HISTORY AND EPIDEMIOLOGY

Book Title : Goldfrank'sToxicologic Emergencies, 11e

BOOK CHAPTER

Chapter 31: Opioid Analgesics & Antagonists

Book Title : Katzung & Trevor's Pharmacology: Examination & Board Review, 12e

BOOK CHAPTER

Chapter 3: Stereochemistry

Book Title : The Organic Chemistry of Medicinal Agents

Book Title :

Brenner and Stevens’ Pharmacology, Fifth Edition

Book Title :

Brody's Human Pharmacology, Sixth Edition

Book Title :

Dale's Pharmacology Condensed, Third Edition

Book Title :

Infectious Disease and Pharmacology: Neonatology Questions and Controversies

CHAPTER EXCERPT

Pharmacology of Protein and Oligonucleotide Pharmaceuticals

How drugs act : Biopharmaceuticals and gene therapy ›Oligonucleotides

There are important differences between the pharmacological properties of protein and oligonucleotide biopharmaceuticals and those of conventional small molecule drugs ( Table 5.2), attributable in part to their difference in molecular mass. Most ...

Rang & Dale's Pharmacology .

See more results from this chapter

CHAPTER EXCERPT

Pharmacokinetic and pharmaceutical aspects

The heart  ›Drugs That Affect Cardiac Function ›Anti-Anginal Drugs ›Organic Nitrates

Glyceryl trinitrate is rapidly inactivated by hepatic metabolism. It is well absorbed from the mouth and is taken as a tablet under the tongue or as a sublingual spray, producing its effects within a few minutes. If swallowed, it is ineffective be...

Rang & Dale's Pharmacology  .

CHAPTER EXCERPT

Pharmaceutical factors 7

General pharmacology  › …› Absorption › Systemic availability and bioavailability

Some definitions of enteral dose forms. Tablet: a solid dose form in which the drug is compressed or moulded with pharmacologically inert substances (excipients); variants include sustained-release and coated tablets. Capsule: the drug is provided...

Clinical Pharmacology  .

CHAPTER EXCERPT

Biotechnology-derived pharmaceuticals

Discovery and development of drugs ›Studies in animals 9

– present a special case, and the standard regimen of toxicology studies is not appropriate. The choice of species used depends on the expression of the relevant receptor. If no suitable species exists, homologous proteins or transgenic animals ex...

Clinical Pharmacology .

Opioid pharmaceuticals and addiction: The issues, and research directions seeking solutions

Fig. 2:Mu receptor signaling complexes. (A) Mu receptor signaling complexes. Agonists of the mu receptor bind to extracellular regions of this GPCR. This leads to dissociation of the cognate G-proteins from the receptor which, either through a conformati... More

Drug and Alcohol Dependence.

Walwyn, Wendy M.; Miotto, Karen A.; Evans, Christopher J... Published May 1, 2010. Volume 108, Issue 3. Pages 156-165. © 2010.

Knocking out or pharmaceutical inhibition of fatty acid binding protein 4 (FABP4) alleviates osteoarthritis induced by high-fat diet in mice

Fig. 2:Knocking out or pharmaceutical inhibition of FABP4 significantly alleviated cartilage degradation at early stage of OA in animals fed with HFD. The coronal sections of knees were stained with Safranin O and Fast Green. (A–F) Representative images ... More

Osteoarthritis and Cartilage.

Zhang, C.; Chiu, K.Y.; Chan, B.P.M.; Li, T.; Wen, C.; Xu, A.; Yan, C.H... Published June 1, 2018. Volume 26, Issue 6. Pages 824-833. © 2018.

Self-indicating, fully active pharmaceutical ingredients nanoparticles (FAPIN) for multimodal imaging guided trimodality cancer therapy  

Fig. 4:a) Ex vivo distribution of PaIr NPs indicated by intrinsic NIRF, Pa + Ir mixture treated groups were set as control. To illustrate the effect of laser, mice were inoculated with two tumors on each flank, and one tumor was treated with laser. The u... More

Biomaterials.

Xue, Xiangdong; Huang, Yee; Wang, Xinshuai; Wang, Zhongling; Carney, Randy P.; Li, Xiaocen; Yuan, Ye; He, Yixuan; Lin, Tzu-yin; Li, Yuanpei.. Published April 1, 2018. Volume 161. Pages 203-215. © 2018.

Pharmaceutical nanocarrier association with chondrocytes and cartilage explants: influence of surface modification and extracellular matrix depletion

Fig. 4:Impact of IL-1α and trypsin treatments on rhodamine-labeled micelles and liposomes' association with cartilage explants. A: Normalized fluorescence intensity in control and IL-1 stimulated bovine cartilage explants. Treatment with rhodamine-labele... More

Osteoarthritis and Cartilage.

Elsaid, K.A.; Ferreira, L.; Truong, T.; Liang, A.; Machan, J.; D'Souza, G.G... Published February 1, 2013. Volume 21, Issue 2. Pages 377-384. © 2012

Techniques in Vascular and Interventional Radiology.

Techniques in Vascular and Interventional Radiology.

Show more…

Techniques in Vascular and Interventional Radiology.

Show more…

Techniques in Vascular and Interventional Radiology.

Show more…

Techniques in Vascular and Interventional Radiology.

Show more…

Techniques in Vascular and Interventional Radiology.

Fig. 1.12 Plasma concentration of drugs with irregular dosing.

Irregular dosing, such as occurs with the increased nocturnal dosing interval with fixed-dose/fixed-time-interval regimens or due to missed doses (poor patient compliance), results in the plasma drug concentration falling below the desired therapeutic level (pink areas). It then takes several doses to reach the desired therapeutic level once again. Note that the arrows signify when each dose of drug is taken and the question mark (?) represents a missed dose.

Source: 1.8 Pharmacokinetics of Drug Administration in Practice . In: Simmons M, ed. Pharmacology—An Illustrated Review. 1st Edition. Thieme; 2011. doi:10.1055/b-005-148943

Fig. 3.2 Pregnancy: fetal damage due to drugs.

The sequelae of a drug taken during pregnancy depends on the stage of fetal development and the ability of the drug to cross the placenta.

Source: 3.4 The Pregnant Patient . In: Simmons M, ed. Pharmacology—An Illustrated Review. 1st Edition. Thieme; 2011. doi:10.1055/b-005-148943

Fig. 1.1 Mode of administration and time course of plasma drug concentration.

Drugs given intravenously (red) reach their peak plasma drug concentration almost immediately, but this declines rapidly as the drug is distributed and eliminated. Drugs given intramuscularly (green) take longer to reach their peak plasma concentration, followed by drugs given subcutaneously (blue). Drugs taken orally (purple) are the slowest to reach their peak plasma concentration, the value of which is determined by bioavailability following first-pass metabolism.

Source: 1.1 Routes of Drug Administration . In: Simmons M, ed. Pharmacology—An Illustrated Review. 1st Edition. Thieme; 2011. doi:10.1055/b-005-148943

Fig. 34.7 Immune reaction and immunosuppressant drugs.

Humoral immunity (left column) and cell-mediated immunity (middle two columns) are described in the call-out boxes, on p. 383. The far right column lists the actions of immunosuppressant drugs in inhibiting immune responses. (MHC, major histocompatibility complex)

Source: 34.3 Immunosuppressants . In: Simmons M, ed. Pharmacology—An Illustrated Review. 1st Edition. Thieme; 2011. doi:10.1055/b-005-148943