ClinicalKey

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Pharmacology of Protein and Oligonucleotide Pharmaceuticals

How drugs act : Biopharmaceuticals and gene therapy ›Oligonucleotides

There are important differences between the pharmacological properties of protein and oligonucleotide biopharmaceuticals and those of conventional small molecule drugs ( Table 5.2), attributable in part to their difference in molecular mass. Most ...

Rang & Dale's Pharmacology .

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Pharmacokinetic and pharmaceutical aspects

The heart  ›Drugs That Affect Cardiac Function ›Anti-Anginal Drugs ›Organic Nitrates

Glyceryl trinitrate is rapidly inactivated by hepatic metabolism. It is well absorbed from the mouth and is taken as a tablet under the tongue or as a sublingual spray, producing its effects within a few minutes. If swallowed, it is ineffective be...

Rang & Dale's Pharmacology  .

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Pharmaceutical factors 7

General pharmacology  › …› Absorption › Systemic availability and bioavailability

Some definitions of enteral dose forms. Tablet: a solid dose form in which the drug is compressed or moulded with pharmacologically inert substances (excipients); variants include sustained-release and coated tablets. Capsule: the drug is provided...

Clinical Pharmacology  .

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Biotechnology-derived pharmaceuticals

Discovery and development of drugs ›Studies in animals 9

– present a special case, and the standard regimen of toxicology studies is not appropriate. The choice of species used depends on the expression of the relevant receptor. If no suitable species exists, homologous proteins or transgenic animals ex...

CLINICAL PHARMACOLOGY .