ClinicalKey

Opioid pharmaceuticals and addiction: The issues, and research directions seeking solutions

Fig. 2:Mu receptor signaling complexes. (A) Mu receptor signaling complexes. Agonists of the mu receptor bind to extracellular regions of this GPCR. This leads to dissociation of the cognate G-proteins from the receptor which, either through a conformati... More

Drug and Alcohol Dependence.

Walwyn, Wendy M.; Miotto, Karen A.; Evans, Christopher J... Published May 1, 2010. Volume 108, Issue 3. Pages 156-165. © 2010

Knocking out or pharmaceutical inhibition of fatty acid binding protein 4 (FABP4) alleviates osteoarthritis induced by high-fat diet in mice

Fig. 2:Knocking out or pharmaceutical inhibition of FABP4 significantly alleviated cartilage degradation at early stage of OA in animals fed with HFD. The coronal sections of knees were stained with Safranin O and Fast Green. (A–F) Representative images ... More

Osteoarthritis and Cartilage.

Zhang, C.; Chiu, K.Y.; Chan, B.P.M.; Li, T.; Wen, C.; Xu, A.; Yan, C.H... Published June 1, 2018. Volume 26, Issue 6. Pages 824-833. © 2018.

Self-indicating, fully active pharmaceutical ingredients nanoparticles (FAPIN) for multimodal imaging guided trimodality cancer therapy 

Fig. 4:a) Ex vivo distribution of PaIr NPs indicated by intrinsic NIRF, Pa + Ir mixture treated groups were set as control. To illustrate the effect of laser, mice were inoculated with two tumors on each flank, and one tumor was treated with laser. The u... More

Biomaterials.

Xue, Xiangdong; Huang, Yee; Wang, Xinshuai; Wang, Zhongling; Carney, Randy P.; Li, Xiaocen; Yuan, Ye; He, Yixuan; Lin, Tzu-yin; Li, Yuanpei.. Published April 1, 2018. Volume 161. Pages 203-215. © 2018.

Pharmaceutical nanocarrier association with chondrocytes and cartilage explants: influence of surface modification and extracellular matrix depletion

Fig. 4:Impact of IL-1α and trypsin treatments on rhodamine-labeled micelles and liposomes' association with cartilage explants. A: Normalized fluorescence intensity in control and IL-1 stimulated bovine cartilage explants. Treatment with rhodamine-labele... More

Osteoarthritis and Cartilage.

Elsaid, K.A.; Ferreira, L.; Truong, T.; Liang, A.; Machan, J.; D'Souza, G.G... Published February 1, 2013. Volume 21, Issue 2. Pages 377-384. © 2012