ClinicalKey

Book Title :

Brenner and Stevens’ Pharmacology, Fifth Edition

Book Title :

Brody's Human Pharmacology, Sixth Edition

Book Title :

Dale's Pharmacology Condensed, Third Edition

Book Title :

Infectious Disease and Pharmacology: Neonatology Questions and Controversies

CHAPTER EXCERPT

Pharmacology of Protein and Oligonucleotide Pharmaceuticals

How drugs act : Biopharmaceuticals and gene therapy ›Oligonucleotides

There are important differences between the pharmacological properties of protein and oligonucleotide biopharmaceuticals and those of conventional small molecule drugs ( Table 5.2), attributable in part to their difference in molecular mass. Most ...

Rang & Dale's Pharmacology .

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CHAPTER EXCERPT

Pharmacokinetic and pharmaceutical aspects

The heart  ›Drugs That Affect Cardiac Function ›Anti-Anginal Drugs ›Organic Nitrates

Glyceryl trinitrate is rapidly inactivated by hepatic metabolism. It is well absorbed from the mouth and is taken as a tablet under the tongue or as a sublingual spray, producing its effects within a few minutes. If swallowed, it is ineffective be...

Rang & Dale's Pharmacology  .

CHAPTER EXCERPT

Pharmaceutical factors 7

General pharmacology  › …› Absorption › Systemic availability and bioavailability

Some definitions of enteral dose forms. Tablet: a solid dose form in which the drug is compressed or moulded with pharmacologically inert substances (excipients); variants include sustained-release and coated tablets. Capsule: the drug is provided...

Clinical Pharmacology  .

CHAPTER EXCERPT

Biotechnology-derived pharmaceuticals

Discovery and development of drugs ›Studies in animals 9

– present a special case, and the standard regimen of toxicology studies is not appropriate. The choice of species used depends on the expression of the relevant receptor. If no suitable species exists, homologous proteins or transgenic animals ex...

CLINICAL PHARMACOLOGY .

Opioid pharmaceuticals and addiction: The issues, and research directions seeking solutions

Fig. 2:Mu receptor signaling complexes. (A) Mu receptor signaling complexes. Agonists of the mu receptor bind to extracellular regions of this GPCR. This leads to dissociation of the cognate G-proteins from the receptor which, either through a conformati... More

Drug and Alcohol Dependence.

Walwyn, Wendy M.; Miotto, Karen A.; Evans, Christopher J... Published May 1, 2010. Volume 108, Issue 3. Pages 156-165. © 2010.

Knocking out or pharmaceutical inhibition of fatty acid binding protein 4 (FABP4) alleviates osteoarthritis induced by high-fat diet in mice

Fig. 2:Knocking out or pharmaceutical inhibition of FABP4 significantly alleviated cartilage degradation at early stage of OA in animals fed with HFD. The coronal sections of knees were stained with Safranin O and Fast Green. (A–F) Representative images ... More

Osteoarthritis and Cartilage.

Zhang, C.; Chiu, K.Y.; Chan, B.P.M.; Li, T.; Wen, C.; Xu, A.; Yan, C.H... Published June 1, 2018. Volume 26, Issue 6. Pages 824-833. © 2018.

Self-indicating, fully active pharmaceutical ingredients nanoparticles (FAPIN) for multimodal imaging guided trimodality cancer therapy  

Fig. 4:a) Ex vivo distribution of PaIr NPs indicated by intrinsic NIRF, Pa + Ir mixture treated groups were set as control. To illustrate the effect of laser, mice were inoculated with two tumors on each flank, and one tumor was treated with laser. The u... More

Biomaterials.

Xue, Xiangdong; Huang, Yee; Wang, Xinshuai; Wang, Zhongling; Carney, Randy P.; Li, Xiaocen; Yuan, Ye; He, Yixuan; Lin, Tzu-yin; Li, Yuanpei.. Published April 1, 2018. Volume 161. Pages 203-215. © 2018.

Pharmaceutical nanocarrier association with chondrocytes and cartilage explants: influence of surface modification and extracellular matrix depletion

Fig. 4:Impact of IL-1α and trypsin treatments on rhodamine-labeled micelles and liposomes' association with cartilage explants. A: Normalized fluorescence intensity in control and IL-1 stimulated bovine cartilage explants. Treatment with rhodamine-labele... More

Osteoarthritis and Cartilage.

Elsaid, K.A.; Ferreira, L.; Truong, T.; Liang, A.; Machan, J.; D'Souza, G.G... Published February 1, 2013. Volume 21, Issue 2. Pages 377-384. © 2012